Autoimmune thrombocytopenia. Is it a different disease or different aspects of a single disease?

To evaluate the association between autoimmune thrombocytopenia with other autoimmune disorders, to show if they are different autoimmune diseases or one disease with different presentations at the same time, and to study the effect of treatment on platelet count in different thyroid condition. In this retrospective study, we included 141 patients with thrombocytopenic purpura. The result of thyroid function test, thyroid autoantibodies, Coombs' reactivity, anti-nuclear antibody, and double-stranded DNA were analyzed. This study was conducted in the Clinical Hematology Department, King Abdulaziz University Hospital, Jeddah, Saudi Arabia between June 2003 and August 2010. There were 51 [36.2%] patients with laboratory evidence of autoimmune disease, 13 [9.2%] with hypothyroidism, and 6 [4.3%] with hyperthyroidism. In addition, 5 [3.5%] patients showed laboratory evidence of Evan syndrome and 3 [2.1%] patients had isolated positive thyroid antibodies. There was non-significant difference [p=0.61] in platelets count after one month of treatment of patients with different thyroid condition. Immune thrombocytopenia is associated with evidence of different autoimmune disease or a combination of them, which may appear at presentation or during the course of disease giving evidence that they are different manifestations of a single disease. Screening patients for antithyroid antibodies would identify a patient at risk of developing overt thyroid disease. These patients may be further screened with a thyroid-stimulating hormone assay to detect subclinical thyroid disease

Gastrointestinal non-Hodgkin's lymphoma clinico-pathologic study

The aim of this study is to determine the clinicopathologic features of primary gastrointestinal non-Hodgkin's lymphorma [GL NHL] at king Abdulaziz Universaty Hospital-Jeddah, and to compare our results to those reported in the literatures. Twenty three adult patients with primary GI NHL diagnosed over 5- years period [2000-2005] were retrospectively studied clinically and histopathotogicaliy. They were classified using the REAL/WHO histopathologic classification. Of the 23 patients with primary Gl NHL, 14 [60.9%] were Saudi, with male to female ratio of 1.3:1. The mean age of the male patients was 61.3 years ranging from [42-83] years with a SD +/- 13.09 while for females was 64 years, age range [50-75] with a SD +/- 9.14. Abdominal pain was the most common presenting symptoms [78.3%] and the most common primary site was the stomach [73.9%] followed by the small bowel [13 %]. The most frequent histologic subtype was the diffuse large-B cell lymphoma accounting for [60.9%] of all cases, followed by marginal-zone cell lymphoma [MALT type] which was Helicobacter pylori associated in [39.1%]. A large proportion of patients with primary GI NHL had early disease [Stage IE: 20%. Stage IIE 58.6%]. In regards to treatment 15 patients [65.2%] had chemotherapy, while only 2 patients [8.7%] were treated by Helicopter pylori eradication. The overall 5 years survival was [47.8%]. The data demonstrated that primary GI NHL is more common among males, mainly in their sixth decade. Abdominal pain is the most common diagnostic symptoms, with being the most common involved site. Diffuse large-B cell lymphoma is the most frequent histologic subtype, followed by extra-nodal marginal zone B-cell lymphoma [MALT type] Helicobacter associated. The majorities of the cases have early disease [Stage IE and IIE] and mostly treated by combination chemotherapy

Clinico pathological pattern of Non-Hodgkin's lymphoma in the western region of Saudi Arabia

The aim of this study was to analyze the clinical and histopathologic distribution of various types of non-Hodgkin's lymphoma [NHL] at King Abdulaziz University Hospital - Jeddah, and to compare our results with those reported in the literature. A hundred and nine patients with malignant NHL diagnosed over a 10-year period [1994-2004] were retrospectively studied clinically and histopathologically. They were classified using the international working formulation, and recorded in a structured questionnaire. Of the 109 patients with NHL, 42 [47.2%] were Saudi and 67 [75.3%] were Non-Saudi, with male to female ratio of 1.7:1. The mean age of the patients was 48 years, age range [12-93 years]. Diffuse large B-cell lymphoma of intermediate grade was the most frequent histopathological diagnosis 48 [53.9%] followed by high grade 28 [31.5%] and 13 [14.6%] low grade lymphoma. The proportion of primary extranodal NHL was 20 [18.3%] with stomach being the commonest site 9 [45%]. Immunologically, the percentage of NHL with B-cell and T-cell phenotype were 92 [84.4] and 17 [15.7] respectively. Complete remission was achieved in 24 [27%] of patients with nodal presentation and 5 [25%] with extranodal NHL. Prevalence of its advanced stage of the disease 58 [65.1%] and B symptoms 68 [80%] of nodal cases, 11 [55%] of extranodal NHL patients were recognized. The distribution of various types of Non-Hodgkin's lymphoma showed clinical and histopathological similarities and differences when compared with other Non-Hodgkin's lymphoma series from the region, Asian countries or the West. Larger studies using the new WHO classification of lymphomas should be considered

Gastrointestinal non-hodgkins lymphoma clinico-pathologic study

The aim of this study is to determine the clinicopathologic features of primary gastrointestinal non-Hodgkinis lymphoma [GI NHL] at King Abdulaziz University Hospital-Jeddah, and to compare our results to those reported in the literatures. Twenty three adult patients with primary GI NHL diagnosed over 5-years period [2000-2005] were retrospectively studied clinically and histopathologically. They were classified using the REAL/WHO histopathologic classification. Of the 23 patients with primary GI NHL, 14 [60.9%] were Saudi, with male to female ratio of 1.3:1. The mean age of the male patients was 61. 3 years ranging from [42-83] years with a SD +/- 13.09 while for females was 64 years, age range [50-75] with a SD +/- 9.14. Abdominal pain was the most common presenting symptom [78.3%] and the most common primary site was the stomach [73.9%] followed by the small bowel [13%]. The most frequent histologic subtype was the diffuse large-B cell lymphoma accounting for [60.9%] of all cases, followed by marginal-zone cell lymphoma [MALT type] which was Helicobacter pylori associated in [39.1%]. A large proportion of patients with primary GI NHL had early disease [Stage IE: 20%, Stage IIE 58.6%]. In regards to treatment 15 patients [65.2%] had chemotherapy, while only 2 patients [8.7%] were treated by Helicobacter pylori eradication. The overall 5 years survival was 47.8%. The data demohstrated that primary GI NHL is more common among males, mainly in their sixth decade. Abdominal pain is the most common diagnostic symptom, with stomach being the most common involved site. Diffuse large-B cell lymphoma is the most frequent histologic subtype, followed by extra-nodal marginal zone B-cell lymphoma [MALT type], Helicobacter associated. The majority of the cases have early disease [Stage IE and IIE] and mostly treated by combination chemotherapy